Version 5.4
Mus musculus Protein: Hrsp12
Summary
InnateDB Protein IDBP-133788.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hrsp12
Protein Name heat-responsive protein 12
Synonyms HR12; HRP12;
Species Mus musculus
Ensembl Protein ENSMUSP00000022946
InnateDB Gene IDBG-133786 (Hrsp12)
Protein Structure
UniProt Annotation
Function Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed predominantly in liver and kidney. Lower levels in lung and brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004519 endonuclease activity
GO:0019239 deaminase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1095401
InterPro IPR006056 Enamine/imine deaminase YjgF-like
IPR006175 YjgF/Yer057p/UK114 family
IPR013813 Endoribonuclease L-PSP/chorismate mutase-like
PFAM PF01042
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P52760
PhosphoSite PhosphoSite-P52760
TrEMBL
UniProt Splice Variant
Entrez Gene 15473
UniGene Mm.488544
RefSeq NP_032313
MGI ID
MGI Symbol Hrsp12
OMIM
CCDS CCDS27418
HPRD
IMGT
EMBL BC092375 BC125590 BC125592 U50631
GenPept AAA96033 AAH92375 AAI25591 AAI25593

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca