InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bfar

Summary

InnateDB Protein

IDBP-133942.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bfar

Protein Name

bifunctional apoptosis regulator

Synonyms

3010001A07Rik; AI666707; AW107665; Bar; Rnf47;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023365

InnateDB Gene

IDBG-133938 (Bfar)

Protein Structure

UniProt Annotation

Function

Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1914368

InterPro

IPR001660 Sterile alpha motif domain
IPR001841 Zinc finger, RING-type
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR018957 Zinc finger, C3HC4 RING-type
IPR021129 Sterile alpha motif, type 1

PFAM

PF13639
PF14634
PF07647
PF00097
PF00536

PRINTS

PIRSF

SMART

SM00454
SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R079