InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ankrd6

Summary

InnateDB Protein

IDBP-133951.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ankrd6

Protein Name

ankyrin repeat domain 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081801

InnateDB Gene

IDBG-133945 (Ankrd6)

Protein Structure

UniProt Annotation

Function

Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals. {ECO:0000269PubMed:12183362}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0046330	positive regulation of JNK cascade
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000096	positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway