InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NAGPA

Summary

InnateDB Protein

IDBP-13399.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAGPA

Protein Name

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000371381

InnateDB Gene

IDBG-13395 (NAGPA)

Protein Structure

UniProt Annotation

Function

Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P- mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N- acetylglucosaminyltransferases. {ECO:0000269PubMed:23572527}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000269PubMed:12058031}; Single-pass type I membrane protein {ECO:0000269PubMed:12058031}. Golgi apparatus, trans-Golgi network {ECO:0000269PubMed:12058031}. Note=Cis/medial Golgi.

Disease Associations

Tissue Specificity

Isoform 2 may be brain-specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	4 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003944	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
GO:0005515	protein binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006464	cellular protein modification process
GO:0006486	protein glycosylation
GO:0006622	protein targeting to lysosome
GO:0007040	lysosome organization