InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rrn3

Summary

InnateDB Protein

IDBP-134080.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rrn3

Protein Name

RRN3 RNA polymerase I transcription factor homolog (yeast)

Synonyms

AL023001; E130302O19Rik; R75565; TIF-1A; Tif1a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023363

InnateDB Gene

IDBG-134078 (Rrn3)

Protein Structure

UniProt Annotation

Function

Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction. {ECO:0000269PubMed:12015311, ECO:0000269PubMed:12646563}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:12015311}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0070063	RNA polymerase binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006352	DNA-templated transcription, initiation
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0007000	nucleolus organization
GO:0007028	cytoplasm organization
GO:0008283	cell proliferation
GO:0042254	ribosome biogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048872	homeostasis of number of cells
GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:2000142	regulation of DNA-dependent transcription, initiation