InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: F10

Summary

InnateDB Protein

IDBP-134273.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F10

Protein Name

coagulation factor X

Synonyms

Cf10; fX;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000068389

InnateDB Gene

IDBG-134269 (F10)

Protein Structure

UniProt Annotation

Function

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Plasma; synthesized in the liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005543	phospholipid binding

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005576	extracellular region
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:103107

InterPro

IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
IPR000742 Epidermal growth factor-like domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR001881 EGF-like calcium-binding domain
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z

PFAM

PF00594
PF00008
PF00089
PF07645

PRINTS

PR00001
PR00722

PIRSF

PIRSF001143

SMART

SM00069
SM00181
SM00020
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References