Version 5.4
Mus musculus Protein: Nceh1
Summary
InnateDB Protein IDBP-134298.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nceh1
Protein Name arylacetamide deacetylase-like 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000045864
InnateDB Gene IDBG-134294 (Nceh1)
Protein Structure
UniProt Annotation
Function Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. {ECO:0000269PubMed:15840715, ECO:0000269PubMed:16978018, ECO:0000269PubMed:18164358, ECO:0000269PubMed:18782767}.
Subcellular Localization Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Microsome {ECO:0000269PubMed:18782767}.
Disease Associations
Tissue Specificity Present in brain, heart, kidney, lung, spinal cord and testis but not liver (at protein level). Expressed in peritoneal macrophages and kidney. {ECO:0000269PubMed:16978018, ECO:0000269PubMed:18782767}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0017171 serine hydrolase activity
GO:0042301 phosphate ion binding
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2443191
InterPro IPR013094 Alpha/beta hydrolase fold-3
IPR017157 Arylacetamide deacetylase
IPR029058 Alpha/Beta hydrolase fold
PFAM PF07859
PRINTS
PIRSF PIRSF037251
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BLF1
PhosphoSite PhosphoSite-Q8BLF1
TrEMBL
UniProt Splice Variant
Entrez Gene 320024
UniGene Mm.481477
RefSeq NP_848887
MGI ID
MGI Symbol Nceh1
OMIM
CCDS CCDS17271
HPRD
IMGT
EMBL AK034339 AK045363 AK135837 AK173158 BC082569
GenPept AAH82569 BAC28680 BAC32327 BAD32436 BAE22685

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca