Mus musculus Protein: Apc
InnateDB Protein IDBP-134577.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Apc
Protein Name adenomatosis polyposis coli
Synonyms AI047805; AU020952; AW124434; CC1; mAPC; Min;
Species Mus musculus
Ensembl Protein ENSMUSP00000064214
InnateDB Gene IDBG-134573 (Apc)
Protein Structure
UniProt Annotation
Subcellular Localization
Disease Associations
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 133 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 35 [view]
Predicted by orthology
Total 133 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0051010 microtubule plus-end binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0001822 kidney development
GO:0001942 hair follicle development
GO:0006974 cellular response to DNA damage stimulus
GO:0007026 negative regulation of microtubule depolymerization
GO:0007050 cell cycle arrest
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007389 pattern specification process
GO:0007409 axonogenesis
GO:0008285 negative regulation of cell proliferation
GO:0009798 axis specification
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0016055 Wnt signaling pathway
GO:0016477 cell migration
GO:0019827 stem cell maintenance
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0031116 positive regulation of microtubule polymerization
GO:0031122 cytoplasmic microtubule organization
GO:0033077 T cell differentiation in thymus
GO:0035019 somatic stem cell maintenance
GO:0042483 negative regulation of odontogenesis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043409 negative regulation of MAPK cascade
GO:0043588 skin development
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045785 positive regulation of cell adhesion
GO:0046716 muscle cell cellular homeostasis
GO:0048538 thymus development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051171 regulation of nitrogen compound metabolic process
GO:0051276 chromosome organization
GO:0051726 regulation of cell cycle
GO:0051781 positive regulation of cell division
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0060041 retina development in camera-type eye
GO:0060070 canonical Wnt signaling pathway
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005881 cytoplasmic microtubule
GO:0030424 axon
GO:0030426 growth cone
GO:0031253 cell projection membrane
GO:0035371 microtubule plus-end
GO:0042995 cell projection
GO:0044295 axonal growth cone
Protein Structure and Domains
PDB ID MGI:88039
InterPro IPR026831 Adenomatous polyposis coli domain
PFAM PF11414
Post-translational Modifications
PhosphoSite PhosphoSite-
UniProt Splice Variant
Entrez Gene 11789
UniGene Mm.470430
MGI Symbol Apc
EMBL AC090534 AC114003 AK042021 AK082724 AL591373
GenPept BAC31134 BAC38587