Version 5.4
Mus musculus Protein: Dmtf1
Summary
InnateDB Protein IDBP-134624.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dmtf1
Protein Name cyclin D binding myb-like transcription factor 1
Synonyms Dimp; Dmp1;
Species Mus musculus
Ensembl Protein ENSMUSP00000092627
InnateDB Gene IDBG-134620 (Dmtf1)
Protein Structure
UniProt Annotation
Function Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. May also cooperate with MYB to activate transcription of the ANPEP gene. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'. {ECO:0000269PubMed:10097151, ECO:0000269PubMed:10898794, ECO:0000269PubMed:11711428, ECO:0000269PubMed:15601844, ECO:0000269PubMed:17936562, ECO:0000269PubMed:8887674, ECO:0000269PubMed:9488476, ECO:0000269PubMed:9786929}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00625, ECO:0000269PubMed:10097151, ECO:0000269PubMed:16878159, ECO:0000269PubMed:17936562, ECO:0000269PubMed:9488476}.
Disease Associations
Tissue Specificity Ubiquitously expressed (at mRNA level). Expressed in brain, intestine, kidney, lung, pancreas, skin, spleen and tongue (at protein level). Expressed at high levels in testis and thymus (at protein level). In all tissues examined, expression is predominant in non-proliferating and differentiated cell types. These include epithelial, interstitial and smooth muscle cells of the intestine, differentiated spermatids, sperm and interstitial cells of the testis, and lymphoid cells of the medullary compartment of the thymus. {ECO:0000269PubMed:10898794, ECO:0000269PubMed:16878159, ECO:0000269PubMed:8887674}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 0
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1344415
InterPro IPR001005 SANT/Myb domain
IPR009057 Homeodomain-like
IPR017877 Myb-like domain
PFAM PF00249
PRINTS
PIRSF
SMART SM00717
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CE22
PhosphoSite PhosphoSite-Q8CE22
TrEMBL V9GXV6
UniProt Splice Variant
Entrez Gene 23857
UniGene Mm.395239
RefSeq NP_001103797
MGI ID
MGI Symbol Dmtf1
OMIM
CCDS CCDS51412
HPRD
IMGT
EMBL AC107763 AC158121 AK029147 AK031887 AK039563 AK046201 AK160595 BC045141 U70017
GenPept AAC52878 AAH45141 BAC26325 BAC27593 BAC30386 BAC32635 BAE35902

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca