InnateDB Protein
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IDBP-134743.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Batf2
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Protein Name
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basic leucine zipper transcription factor, ATF-like 2
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Synonyms
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4933430F08Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000045744
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InnateDB Gene
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IDBG-134741 (Batf2)
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Protein Structure
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Function |
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types. Possibly acts by interfering with AP-1 binding to CYR61 promoter (By similarity). Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. {ECO:0000250, ECO:0000269PubMed:22992524}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00978}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1921731
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InterPro |
IPR004827
Basic-leucine zipper domain
IPR008917
Transcription factor, Skn-1-like, DNA-binding domain
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PFAM |
PF00170
PF07716
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PRINTS |
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PIRSF |
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SMART |
SM00338
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R1H8
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PhosphoSite |
PhosphoSite-Q8R1H8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
74481
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UniGene |
Mm.490074
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RefSeq |
NP_083243
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MGI ID |
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MGI Symbol |
Batf2
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OMIM |
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CCDS |
CCDS29497
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HPRD |
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IMGT |
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EMBL |
AK150133
AK171828
BC024521
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GenPept |
AAH24521
BAE29330
BAE42686
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