Version 5.4
Homo sapiens Protein: KLF3
Summary
InnateDB Protein IDBP-13489.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLF3
Protein Name Kruppel-like factor 3 (basic)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000261438
InnateDB Gene IDBG-13485 (KLF3)
Protein Structure
UniProt Annotation
Function Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:1901653 cellular response to peptide
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR029033 Histidine phosphatase superfamily
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P57682
PhosphoSite PhosphoSite-P57682
TrEMBL A0A024R9T8
UniProt Splice Variant
Entrez Gene 51274
UniGene Hs.704504
RefSeq NP_057615
HUGO HGNC:16516
OMIM 609392
CCDS CCDS3444
HPRD 13920
IMGT
EMBL AB024523 AF285837 BC030662 BC051687 CH471069
GenPept AAH30662 AAH51687 AAK27329 BAA92271 EAW92895 EAW92896

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca