InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxo43

Summary

InnateDB Protein

IDBP-134922.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo43

Protein Name

F-box protein 43

Synonyms

4930533G20Rik; Emi2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054125

InnateDB Gene

IDBG-134920 (Fbxo43)

Protein Structure

UniProt Annotation

Function

Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. {ECO:0000269PubMed:16456547}.

Subcellular Localization

Disease Associations

Tissue Specificity

Present in testis and ovary (at protein level). Expression is high in immature oocytes, and diminishes after oocyte activation. {ECO:0000269PubMed:16456547}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0007126	meiotic nuclear division
GO:0016567	protein ubiquitination
GO:0040020	regulation of meiosis
GO:0042177	negative regulation of protein catabolic process
GO:0045835	negative regulation of meiosis