Version 5.4
Mus musculus Protein: Agr2
Summary
InnateDB Protein IDBP-135065.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Agr2
Protein Name anterior gradient 2 (Xenopus laevis)
Synonyms Agr2h; Gob-4; HAG-2; mAG-2; XAG-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000020898
InnateDB Gene IDBG-135063 (Agr2)
Protein Structure
UniProt Annotation
Function Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}. Endoplasmic reticulum {ECO:0000269PubMed:19359471}.
Disease Associations
Tissue Specificity Expressed in lung, skeletal muscle, testis, liver, stomach, colon, small intestine, the goblet cells of the intestine and the mucuous neck cells of the stomach. {ECO:0000269PubMed:10095068, ECO:0000269PubMed:9790916}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002162 dystroglycan binding
GO:0005515 protein binding
Biological Process
GO:0060480 lung goblet cell differentiation
GO:0070254 mucus secretion
Cellular Component
GO:0005576 extracellular region
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID MGI:1344405
InterPro IPR012336 Thioredoxin-like fold
PFAM PF13098
PF13192
PF13462
PF13905
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88312
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 23795
UniGene Mm.464703
RefSeq NP_035913
MGI ID
MGI Symbol Agr2
OMIM
CCDS CCDS25881
HPRD
IMGT
EMBL AB016592 AF044262 AK007677 BC013334 CT030196
GenPept AAC72705 AAH13334 BAA32044 BAB25181 CAM19620

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca