Version 5.4
| Mus musculus Protein: Usp11 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-135117.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Usp11 | ||||||||
| Protein Name | ubiquitin specific peptidase 11 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000033383 | ||||||||
| InnateDB Gene | IDBG-135115 (Usp11) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. Associates with chromatin (By similarity). {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2384312 | ||||||||
| InterPro |
IPR001394
Peptidase C19, ubiquitin carboxyl-terminal hydrolase IPR006615 Peptidase C19, ubiquitin-specific peptidase, DUSP domain IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain IPR029071 Ubiquitin-related domain |
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| PFAM |
PF00443
PF06337 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00695
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q99K46 | ||||||||
| PhosphoSite | PhosphoSite-Q99K46 | ||||||||
| TrEMBL | Q8BX45 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 236733 | ||||||||
| UniGene | Mm.34489 | ||||||||
| RefSeq | NP_663603 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Usp11 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS53015 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK049053 AK166523 AK169116 AK220478 AL807240 BC005470 CH466625 | ||||||||
| GenPept | AAH05470 BAC33526 BAD90502 BAE38827 BAE40896 CAM23095 EDL00740 | ||||||||