InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snai2

Summary

InnateDB Protein

IDBP-135464.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snai2

Protein Name

snail homolog 2 (Drosophila)

Synonyms

Slug; Slugh; Snail2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023356

InnateDB Gene

IDBG-135462 (Snai2)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box- containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003682	chromatin binding
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001649	osteoblast differentiation
GO:0001837	epithelial to mesenchymal transition
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003273	cell migration involved in endocardial cushion formation
GO:0006366	transcription from RNA polymerase II promoter
GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007219	Notch signaling pathway
GO:0007605	sensory perception of sound
GO:0009314	response to radiation
GO:0009790	embryo development
GO:0010839	negative regulation of keratinocyte proliferation
GO:0010957	negative regulation of vitamin D biosynthetic process
GO:0014032	neural crest cell development
GO:0016477	cell migration
GO:0030335	positive regulation of cell migration
GO:0032331	negative regulation of chondrocyte differentiation
GO:0032642	regulation of chemokine production
GO:0035066	positive regulation of histone acetylation
GO:0035414	negative regulation of catenin import into nucleus
GO:0035921	desmosome disassembly
GO:0036120	cellular response to platelet-derived growth factor stimulus
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043473	pigmentation
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044319	wound healing, spreading of cells
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045600	positive regulation of fat cell differentiation
GO:0045667	regulation of osteoblast differentiation
GO:0050872	white fat cell differentiation
GO:0060021	palate development
GO:0060070	canonical Wnt signaling pathway
GO:0060429	epithelium development
GO:0060536	cartilage morphogenesis
GO:0060693	regulation of branching involved in salivary gland morphogenesis
GO:0070563	negative regulation of vitamin D receptor signaling pathway
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0071479	cellular response to ionizing radiation
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1900387	negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000647	negative regulation of stem cell proliferation
GO:2000810	regulation of tight junction assembly
GO:2000811	negative regulation of anoikis
GO:2001028	positive regulation of endothelial cell chemotaxis
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand