Version 5.4
Mus musculus Protein: Rrm2b
Summary
InnateDB Protein IDBP-135834.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rrm2b
Protein Name ribonucleotide reductase M2 B (TP53 inducible)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000022901
InnateDB Gene IDBG-135832 (Rrm2b)
Protein Structure
UniProt Annotation
Function Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. {ECO:0000269PubMed:11517226, ECO:0000269PubMed:12858174}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates from cytoplasm to nucleus in response to DNA damage. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0001822 kidney development
GO:0003014 renal system process
GO:0006264 mitochondrial DNA replication
GO:0006281 DNA repair
GO:0006979 response to oxidative stress
GO:0009186 deoxyribonucleoside diphosphate metabolic process
GO:0009200 deoxyribonucleoside triphosphate metabolic process
GO:0009263 deoxyribonucleotide biosynthetic process
GO:0055114 oxidation-reduction process
GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2155865
InterPro IPR000358 Ribonucleotide reductase small subunit
IPR009078 Ferritin-like superfamily
PFAM PF00268
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PEE3
PhosphoSite PhosphoSite-
TrEMBL D3Z0X2
UniProt Splice Variant
Entrez Gene 382985
UniGene Mm.473406
RefSeq NP_955770
MGI ID
MGI Symbol Rrm2b
OMIM
CCDS CCDS27437
HPRD
IMGT
EMBL AC122291 AK138731 BC058103
GenPept AAH58103 BAE23760

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca