InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdc25c

Summary

InnateDB Protein

IDBP-135849.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc25c

Protein Name

cell division cycle 25 homolog C (S. pombe)

Synonyms

Cdc25;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055427

InnateDB Gene

IDBG-135847 (Cdc25c)

Protein Structure

UniProt Annotation

Function

Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity). May be involved in regulating the proliferation of T-lymphocytes following cytokine stimulation. {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Spleen and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0050699	WW domain binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000087	mitotic M phase
GO:0006470	protein dephosphorylation
GO:0007067	mitotic nuclear division
GO:0007283	spermatogenesis
GO:0035335	peptidyl-tyrosine dephosphorylation