InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndst2

Summary

InnateDB Protein

IDBP-136113.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndst2

Protein Name

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2

Synonyms

Mndns; NDST-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040227

InnateDB Gene

IDBG-136111 (Ndst2)

Protein Structure

UniProt Annotation

Function

Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. {ECO:0000269PubMed:10466726, ECO:0000269PubMed:10466727}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed in adult and throughout development.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity
GO:0016787	hydrolase activity
GO:0019213	deacetylase activity

Biological Process

GO:0002002	regulation of angiotensin levels in blood
GO:0006024	glycosaminoglycan biosynthetic process
GO:0009987	cellular process
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0030210	heparin biosynthetic process