InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bclaf1

Summary

InnateDB Protein

IDBP-136488.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bclaf1

Protein Name

BCL2-associated transcription factor 1

Synonyms

2610102K23Rik; 2700025J07Rik; 2810454G14Rik; 5730534O06Rik; AI450190; AW556225; Btf; mKIAA0164;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043583

InnateDB Gene

IDBG-136486 (Bclaf1)

Protein Structure

UniProt Annotation

Function

Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043620	regulation of DNA-dependent transcription in response to stress
GO:0045892	negative regulation of transcription, DNA-templated
GO:2000144	positive regulation of DNA-dependent transcription, initiation
GO:2001022	positive regulation of response to DNA damage stimulus
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway