InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hspa9

Summary

InnateDB Protein

IDBP-136513.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspa9

Protein Name

heat shock protein 9

Synonyms

74kDa; Csa; Grp75; Hsc74; Hsp74; Hsp74a; Hspa9a; Mortalin; Mot-2; Mot2; Mthsp70; Pbp74;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025217

InnateDB Gene

IDBG-136511 (Hspa9)

Protein Structure

UniProt Annotation

Function

Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:7865888}. Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Found in all the cell types examined.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 118 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	118 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0005975	carbohydrate metabolic process
GO:0006457	protein folding
GO:0006611	protein export from nucleus

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0042645	mitochondrial nucleoid
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:96245

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR012725 Chaperone DnaK
IPR013126 Heat shock protein 70 family
IPR018485 Carbohydrate kinase, FGGY, C-terminal
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012
PF02782

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P38647