InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pik3ca

Summary

InnateDB Protein

IDBP-136532.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pik3ca

Protein Name

phosphatidylinositol 3-kinase, catalytic, alpha polypeptide

Synonyms

6330412C24Rik; caPI3K; p110; p110alpha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029201

InnateDB Gene

IDBG-136530 (Pik3ca)

Protein Structure

UniProt Annotation

Function

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1- AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. {ECO:0000269PubMed:16625210, ECO:0000269PubMed:16647110, ECO:0000269PubMed:17060635, ECO:0000269PubMed:17540175, ECO:0000269PubMed:18449193, ECO:0000269PubMed:21540297}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0030295	protein kinase activator activity
GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0043560	insulin receptor substrate binding
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Biological Process

GO:0001525	angiogenesis
GO:0006006	glucose metabolic process
GO:0006468	protein phosphorylation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0040014	regulation of multicellular organism growth
GO:0043491	protein kinase B signaling
GO:0043524	negative regulation of neuron apoptotic process
GO:0044029	hypomethylation of CpG island
GO:0045860	positive regulation of protein kinase activity
GO:0046854	phosphatidylinositol phosphorylation
GO:0048015	phosphatidylinositol-mediated signaling
GO:2000270	negative regulation of fibroblast apoptotic process
GO:2000653	regulation of genetic imprinting
GO:2000811	negative regulation of anoikis

Cellular Component

GO:0005886	plasma membrane
GO:0005942	phosphatidylinositol 3-kinase complex
GO:0005943	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

MGI:1206581

InterPro

IPR000008 C2 domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold
IPR029071 Ubiquitin-related domain

PFAM

PF00168
PF00794
PF00454
PF00613
PF00792
PF02192

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00144
SM00146
SM00145
SM00142
SM00143

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt