InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chmp5

Summary

InnateDB Protein

IDBP-136665.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chmp5

Protein Name

charged multivesicular body protein 5

Synonyms

2210412K09Rik; AW545668;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030128

InnateDB Gene

IDBG-136663 (Chmp5)

Protein Structure

UniProt Annotation

Function

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0001919	regulation of receptor recycling
GO:0007040	lysosome organization
GO:0008333	endosome to lysosome transport
GO:0015031	protein transport

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1924209

InterPro

IPR005024 Snf7

PFAM

PF03357

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D7S9

PhosphoSite

PhosphoSite-Q9D7S9

TrEMBL

UniProt Splice Variant

Entrez Gene

76959

UniGene

Mm.415940

RefSeq

NP_084090

MGI ID

MGI Symbol

Chmp5

OMIM

CCDS

CCDS18053

HPRD

IMGT

EMBL

AK008911 AK147058 BC006947

GenPept

AAH06947 BAB25962 BAE27642