InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prdx5

Summary

InnateDB Protein

IDBP-136966.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prdx5

Protein Name

peroxiredoxin 5

Synonyms

AOEB166; AOPP; Pmp20; Prdx6; PrxV;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025904

InnateDB Gene

IDBG-136962 (Prdx5)

Protein Structure

UniProt Annotation

Function

Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.

Subcellular Localization

Mitochondrion. Cytoplasm. Peroxisome.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001016	RNA polymerase III regulatory region DNA binding
GO:0004601	peroxidase activity
GO:0005102	receptor binding
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046983	protein dimerization activity
GO:0072541	peroxynitrite reductase activity

Biological Process

GO:0006979	response to oxidative stress
GO:0016480	negative regulation of transcription from RNA polymerase III promoter
GO:0032967	positive regulation of collagen biosynthetic process
GO:0034614	cellular response to reactive oxygen species
GO:0042744	hydrogen peroxide catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051354	negative regulation of oxidoreductase activity
GO:0055114	oxidation-reduction process
GO:0060785	regulation of apoptosis involved in tissue homeostasis
GO:0070995	NADPH oxidation
GO:2001057	reactive nitrogen species metabolic process
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005782	peroxisomal matrix
GO:0005829	cytosol
GO:0031410	cytoplasmic vesicle
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome