InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itga8

Summary

InnateDB Protein

IDBP-137044.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itga8

Protein Name

integrin alpha 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028106

InnateDB Gene

IDBG-137042 (Itga8)

Protein Structure

UniProt Annotation

Function

Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. {ECO:0000269PubMed:10742111, ECO:0000269PubMed:11470831, ECO:0000269PubMed:11891185, ECO:0000269PubMed:12787402, ECO:0000269PubMed:17537792, ECO:0000269PubMed:9054500, ECO:0000269PubMed:9548928, ECO:0000269PubMed:9614184}.

Subcellular Localization

Membrane {ECO:0000269PubMed:10742111}; Single-pass type I membrane protein {ECO:0000269PubMed:10742111}. Cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

In brain, expressed in deep cortex, hippocampal CA1, basolateral amygdala and striatum. In kidney, expressed in glomerular mesengium (at protein level). {ECO:0000269PubMed:10024342, ECO:0000269PubMed:10504498}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046872	metal ion binding

Biological Process

GO:0001656	metanephros development
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007420	brain development
GO:0007613	memory
GO:0030030	cell projection organization
GO:0030198	extracellular matrix organization
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0042472	inner ear morphogenesis
GO:0045184	establishment of protein localization
GO:0048745	smooth muscle tissue development
GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation

Cellular Component

GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0014069	postsynaptic density
GO:0032591	dendritic spine membrane
GO:0043204	perikaryon
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

MGI:109442

InterPro

IPR000413 Integrin alpha chain
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

PFAM

PF01839
PF14312
PF08441
PF00357

PRINTS

PR01185

PIRSF

SMART

SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt