InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STK17A

Summary

InnateDB Protein

IDBP-13710.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STK17A

Protein Name

serine/threonine kinase 17a

Synonyms

DRAK1;

Species

Homo sapiens

Ensembl Protein

ENSP00000319192

InnateDB Gene

IDBG-13708 (STK17A)

Protein Structure

UniProt Annotation

Function

Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. {ECO:0000269PubMed:21489989, ECO:0000269PubMed:9786912}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9786912}.

Disease Associations

Tissue Specificity

Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:9786912}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:2000271	positive regulation of fibroblast apoptotic process
GO:2000377	regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt