InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aldh8a1

Summary

InnateDB Protein

IDBP-137144.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh8a1

Protein Name

aldehyde dehydrogenase 8 family, member A1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038878

InnateDB Gene

IDBG-137142 (Aldh8a1)

Protein Structure

UniProt Annotation

Function

Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has a preference for NAD, but shows considerable activity with NADP (in vitro) (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12519776}.

Disease Associations

Tissue Specificity

Detected in hepatocytes and in proximal and distal convoluted tubules in kidney cortex (at protein level). Highly expressed in adult liver and in kidney cortex. First detected in embryonic liver after 15 days of development. {ECO:0000269PubMed:12519776}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001758	retinal dehydrogenase activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0008152	metabolic process
GO:0042573	retinoic acid metabolic process
GO:0042574	retinal metabolic process
GO:0042904	9-cis-retinoic acid biosynthetic process
GO:0055114	oxidation-reduction process