InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bad

Summary

InnateDB Protein

IDBP-137337.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bad

Protein Name

BCL2-associated agonist of cell death

Synonyms

AI325008; Bbc2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025910

InnateDB Gene

IDBG-137335 (Bad)

Protein Structure

UniProt Annotation

Function

Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

Subcellular Localization

Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008289	lipid binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0030346	protein phosphatase 2B binding
GO:0043422	protein kinase B binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001836	release of cytochrome c from mitochondria
GO:0006007	glucose catabolic process
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008283	cell proliferation
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009725	response to hormone
GO:0009749	response to glucose
GO:0010033	response to organic substance
GO:0010918	positive regulation of mitochondrial membrane potential
GO:0014070	response to organic cyclic compound
GO:0019050	suppression by virus of host apoptotic process
GO:0019221	cytokine-mediated signaling pathway
GO:0032024	positive regulation of insulin secretion
GO:0032355	response to estradiol
GO:0032570	response to progesterone
GO:0033133	positive regulation of glucokinase activity
GO:0033574	response to testosterone
GO:0034201	response to oleic acid
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0042593	glucose homeostasis
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043200	response to amino acid
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044342	type B pancreatic cell proliferation
GO:0045471	response to ethanol
GO:0045579	positive regulation of B cell differentiation
GO:0045582	positive regulation of T cell differentiation
GO:0045862	positive regulation of proteolysis
GO:0046031	ADP metabolic process
GO:0046034	ATP metabolic process
GO:0046902	regulation of mitochondrial membrane permeability
GO:0046931	pore complex assembly
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051384	response to glucocorticoid
GO:0051592	response to calcium ion
GO:0060139	positive regulation of apoptotic process by virus
GO:0060154	cellular process regulating host cell cycle in response to virus
GO:0071247	cellular response to chromate
GO:0071260	cellular response to mechanical stimulus
GO:0071310	cellular response to organic substance
GO:0071316	cellular response to nicotine
GO:0071396	cellular response to lipid
GO:0071456	cellular response to hypoxia
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097202	activation of cysteine-type endopeptidase activity
GO:1901216	positive regulation of neuron death
GO:2000078	positive regulation of type B pancreatic cell development