Mus musculus Protein: Bad
InnateDB Protein IDBP-137337.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bad
Protein Name BCL2-associated agonist of cell death
Synonyms AI325008; Bbc2;
Species Mus musculus
Ensembl Protein ENSMUSP00000025910
InnateDB Gene IDBG-137335 (Bad)
Protein Structure
UniProt Annotation
Function Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Subcellular Localization Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm.
Disease Associations
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008289 lipid binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030346 protein phosphatase 2B binding
GO:0043422 protein kinase B binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001666 response to hypoxia
GO:0001836 release of cytochrome c from mitochondria
GO:0006007 glucose catabolic process
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008283 cell proliferation
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009725 response to hormone
GO:0009749 response to glucose
GO:0010033 response to organic substance
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0014070 response to organic cyclic compound
GO:0019050 suppression by virus of host apoptotic process
GO:0019221 cytokine-mediated signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0032355 response to estradiol
GO:0032570 response to progesterone
GO:0033133 positive regulation of glucokinase activity
GO:0033574 response to testosterone
GO:0034201 response to oleic acid
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042593 glucose homeostasis
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043200 response to amino acid
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044342 type B pancreatic cell proliferation
GO:0045471 response to ethanol
GO:0045579 positive regulation of B cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045862 positive regulation of proteolysis
GO:0046031 ADP metabolic process
GO:0046034 ATP metabolic process
GO:0046902 regulation of mitochondrial membrane permeability
GO:0046931 pore complex assembly
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051384 response to glucocorticoid
GO:0051592 response to calcium ion
GO:0060139 positive regulation of apoptotic process by virus
GO:0060154 cellular process regulating host cell cycle in response to virus
GO:0071247 cellular response to chromate
GO:0071260 cellular response to mechanical stimulus
GO:0071310 cellular response to organic substance
GO:0071316 cellular response to nicotine
GO:0071396 cellular response to lipid
GO:0071456 cellular response to hypoxia
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097202 activation of cysteine-type endopeptidase activity
GO:1901216 positive regulation of neuron death
GO:2000078 positive regulation of type B pancreatic cell development
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1096330
InterPro IPR018868 Pro-apoptotic Bcl-2 protein, BAD
PFAM PF10514
Post-translational Modifications
SwissProt Q61337
PhosphoSite PhosphoSite-Q61337
UniProt Splice Variant
Entrez Gene 12015
UniGene Mm.4387
RefSeq NP_031548
MGI Symbol Bad
EMBL AC120557 AK131666 AK151792 BC006762 CH466612 L37296
GenPept AAA64465 AAH06762 BAE20753 BAE30693 EDL33265