InnateDB Protein
|
IDBP-137407.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
C1ql3
|
Protein Name
|
C1q-like 3
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000056188
|
InnateDB Gene
|
IDBG-137405 (C1ql3)
|
Protein Structure
|
|
Function |
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production. {ECO:0000269PubMed:21262840, ECO:0000269PubMed:21378161}.
|
Subcellular Localization |
Secreted {ECO:0000269PubMed:21378161}.
|
Disease Associations |
|
Tissue Specificity |
Highly expressed in brain and white adipose tissue. In gonadal fat pad, expressed at lower levels in adipocytes than in the stromal vascular fraction (VSP), which contains preadipocytes, fibroblasts, endothelial cells and occasional immune cells. Expression exhibits sexually dimorphism, with higher levels in females than in males (at protein level). Tends to be up-regulated in adipose tissue from obese males, but not females. Expressed in glial cells. {ECO:0000269PubMed:21378161}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:2387350
|
InterPro |
IPR001073
Complement C1q protein
IPR008160
Collagen triple helix repeat
IPR008983
Tumour necrosis factor-like domain
|
PFAM |
PF00386
PF01391
|
PRINTS |
PR00007
|
PIRSF |
|
SMART |
SM00110
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9ESN4
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
227580
|
UniGene |
|
RefSeq |
NP_694795
|
MGI ID |
|
MGI Symbol |
C1ql3
|
OMIM |
|
CCDS |
CCDS15692
|
HPRD |
|
IMGT |
|
EMBL |
AB044560
AB045983
AL929209
BC024634
CH466542
EU399230
|
GenPept |
AAH24634
ABY86415
BAB15806
BAB59006
CAM23728
EDL08047
|
|
|