Version 5.4
Mus musculus Protein: Samd8
Summary
InnateDB Protein IDBP-137495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Samd8
Protein Name sterile alpha motif domain containing 8
Synonyms 1110053F04Rik; 1700010P07Rik; SMSr;
Species Mus musculus
Ensembl Protein ENSMUSP00000022292
InnateDB Gene IDBG-137493 (Samd8)
Protein Structure
UniProt Annotation
Function sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphatidylethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0016740 transferase activity
Biological Process
GO:0006686 sphingomyelin biosynthetic process
GO:0046513 ceramide biosynthetic process
GO:2000303 regulation of ceramide biosynthetic process
Cellular Component
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID MGI:1914880
InterPro IPR001660 Sterile alpha motif domain
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
PFAM PF00536
PRINTS
PIRSF
SMART SM00454
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DA37
PhosphoSite PhosphoSite-Q9DA37
TrEMBL Q3UH82
UniProt Splice Variant
Entrez Gene 67630
UniGene Mm.422842
RefSeq NP_080559
MGI ID
MGI Symbol Samd8
OMIM
CCDS CCDS26866
HPRD
IMGT
EMBL AC151533 AK006211 AK075749 AK147234 AK147528 AY294423 BC116745 BC116747 CH466613
GenPept AAI16746 AAI16748 AAQ01515 BAB24461 BAC35929 BAE27784 BAE27975 EDL01467

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca