Version 5.4
Mus musculus Protein: Ppp1r14b
Summary
InnateDB Protein IDBP-137644.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp1r14b
Protein Name protein phosphatase 1, regulatory (inhibitor) subunit 14B
Synonyms AOM172; PHI-1; PLCB3N; Png;
Species Mus musculus
Ensembl Protein ENSMUSP00000064129
InnateDB Gene IDBG-137642 (Ppp1r14b)
Protein Structure
UniProt Annotation
Function Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated. {ECO:0000269PubMed:10606530, ECO:0000269PubMed:12144526}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitous. Highly expressed in testis. Detected at low levels in the other tissues tested. Highly expressed in cardiac muscle, bladder and aorta (at protein level). {ECO:0000269PubMed:10606530, ECO:0000269PubMed:8670283}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
GO:0008599 protein phosphatase type 1 regulator activity
Biological Process
GO:0042325 regulation of phosphorylation
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:107682
InterPro IPR008025 PKC-activated phosphatase-1 inhibitor
PFAM PF05361
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62084
PhosphoSite PhosphoSite-Q62084
TrEMBL
UniProt Splice Variant
Entrez Gene 18938
UniGene
RefSeq NP_032915
MGI ID
MGI Symbol Ppp1r14b
OMIM
CCDS CCDS29514
HPRD
IMGT
EMBL BC082545 BC125650 BC125654 X97490
GenPept AAH82545 AAI25651 AAI25655 CAA66121

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca