InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc17a1

Summary

InnateDB Protein

IDBP-137699.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc17a1

Protein Name

solute carrier family 17 (sodium phosphate), member 1

Synonyms

NAPI-1; Napi1; Npt1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006785

InnateDB Gene

IDBG-137697 (Slc17a1)

Protein Structure

UniProt Annotation

Function

Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015114	phosphate ion transmembrane transporter activity
GO:0015293	symporter activity

Biological Process

GO:0006814	sodium ion transport
GO:0035435	phosphate ion transmembrane transport
GO:0046415	urate metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:103209

InterPro

IPR004745 Na-dependent inorganic phosphate cotransporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61983

PhosphoSite