InnateDB Protein
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IDBP-137734.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Vegfb
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Protein Name
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vascular endothelial growth factor B
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Synonyms
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VEGF-B; Vrf;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000025914
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InnateDB Gene
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IDBG-137732 (Vegfb)
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Protein Structure
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Function |
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. VEGF-B seems to be required for normal heart function in adult but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults. {ECO:0000269PubMed:11457758}.
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Subcellular Localization |
Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
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Disease Associations |
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Tissue Specificity |
Abundantly expressed in heart, brain, kidney and skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:106199
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InterPro |
IPR000072
PDGF/VEGF domain
IPR029034
Cystine-knot cytokine
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PFAM |
PF00341
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PRINTS |
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PIRSF |
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SMART |
SM00141
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TIGRFAMs |
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Modification |
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SwissProt |
P49766
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
22340
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UniGene |
Mm.15607
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RefSeq |
NP_035827
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MGI ID |
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MGI Symbol |
Vegfb
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OMIM |
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CCDS |
CCDS29516
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HPRD |
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IMGT |
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EMBL |
AK148188
BC046303
U43836
U43837
U48800
U52820
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GenPept |
AAB06273
AAC52553
AAC52823
AAC52932
AAH46303
BAE28405
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