InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eya4

Summary

InnateDB Protein

IDBP-137826.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eya4

Protein Name

eyes absent 4 homolog (Drosophila)

Synonyms

B130023L16Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073970

InnateDB Gene

IDBG-137824 (Eya4)

Protein Structure

UniProt Annotation

Function

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

In the embryo, expressed mainly in the craniofacial mesenchyme, dermamyotome and limb. {ECO:0000269PubMed:9887327}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004725	protein tyrosine phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007605	sensory perception of sound
GO:0016568	chromatin modification
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042474	middle ear morphogenesis

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1337104

InterPro

IPR006545 EYA domain
IPR023214 HAD-like domain

PFAM

PF00702
PF08282
PF13419

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z191

PhosphoSite

PhosphoSite-Q9Z191

TrEMBL

UniProt Splice Variant

Entrez Gene

14051

UniGene

Mm.332128

RefSeq

XP_006512593

MGI ID

MGI Symbol

Eya4

OMIM

CCDS

HPRD

IMGT

EMBL

AJ007997 BC120899 CH466540 Y17115

GenPept

AAI20900 CAA07820 CAA76637 EDL04766