Version 5.4
Mus musculus Protein: Defb8
Summary
InnateDB Protein IDBP-137992.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Defb8
Protein Name defensin beta 8
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000033854
InnateDB Gene IDBG-137990 (Defb8)
Protein Structure
UniProt Annotation
Function A synthetic peptide displays antimicrobial activities against S.aureus, P.aeruginosa, E.coli and B.cepacia. The antimicrobial activity against S.aureus, E.coli and B.cepacia is reduced in raised concentration of NaCl, but its action against P.aeruginosa is independent of NaCl concentration.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Most highly expressed in testis and heart.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006952 defense response
GO:0042742 defense response to bacterium
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:2654206
InterPro IPR001855 Beta defensin type
PFAM PF00711
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91V82
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 244334
UniGene Mm.390008
RefSeq NP_694748
MGI ID 1E4R
MGI Symbol Defb8
OMIM
CCDS CCDS40259
HPRD
IMGT
EMBL AJ300673 AJ300674 AJ344114
GenPept CAC44634 CAC44635 CAC86998

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca