InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zcchc12

Summary

InnateDB Protein

IDBP-138006.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zcchc12

Protein Name

zinc finger, CCHC domain containing 12

Synonyms

2810028A01Rik; AV136720; Sizn1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044550

InnateDB Gene

IDBG-138004 (Zcchc12)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression. {ECO:0000269PubMed:18160706}.

Subcellular Localization

Disease Associations

Tissue Specificity

In embryonic brains expression is restricted to the ventral region of the forebrain, including the septum, amygdala, caudal putamen, and in the basal-forebrain cholinergic neurons. In adults, expressed in the brain, and at low levels in the testis. {ECO:0000269PubMed:18160706}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0032183	SUMO binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0030509	BMP signaling pathway
GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity