Version 5.4
Mus musculus Protein: Tmem74
Summary
InnateDB Protein IDBP-138177.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem74
Protein Name transmembrane protein 74
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000070748
InnateDB Gene IDBG-138175 (Tmem74)
Protein Structure
UniProt Annotation
Function Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction (By similarity). {ECO:0000250}.
Subcellular Localization Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006914 autophagy
GO:0008150 biological_process
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0005575 cellular_component
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID MGI:2443417
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BQU7
PhosphoSite PhosphoSite-Q8BQU7
TrEMBL
UniProt Splice Variant
Entrez Gene 239408
UniGene Mm.41219
RefSeq NP_780711
MGI ID
MGI Symbol Tmem74
OMIM
CCDS CCDS27454
HPRD
IMGT
EMBL AK046420 BC117021 BC117025
GenPept AAI17022 AAI17026 BAC32721

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca