InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pmpcb

Summary

InnateDB Protein

IDBP-138315.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pmpcb

Protein Name

peptidase (mitochondrial processing) beta

Synonyms

3110004O18Rik; MPP11; MPPB; MPPP52;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030882

InnateDB Gene

IDBG-138313 (Pmpcb)

Protein Structure

UniProt Annotation

Function

Cleaves presequences (transit peptides) from mitochondrial protein precursors. {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004222	metalloendopeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0008152	metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:1920328

InterPro

IPR007863 Peptidase M16, C-terminal domain
IPR011249 Metalloenzyme, LuxS/M16 peptidase-like
IPR011765 Peptidase M16, N-terminal

PFAM

PF05193
PF00675

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CXT8

PhosphoSite

PhosphoSite-

TrEMBL

Q3TET5

UniProt Splice Variant

Entrez Gene

73078

UniGene

Mm.301655

RefSeq

NP_082707

MGI ID

MGI Symbol

Pmpcb

OMIM

CCDS

CCDS19106

HPRD

IMGT

EMBL

AC125313 AC125343 AK013995 AK169417

GenPept

BAB29105 BAE41163