Version 5.4
Mus musculus Protein: Tmem86b
Summary
InnateDB Protein IDBP-138496.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem86b
Protein Name transmembrane protein 86B
Synonyms C330014O21Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000060237
InnateDB Gene IDBG-138494 (Tmem86b)
Protein Structure
UniProt Annotation
Function Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Enriched in liver. Also detected in brain and testis. {ECO:0000269PubMed:21515882}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0047408 alkenylglycerophosphocholine hydrolase activity
GO:0047409 alkenylglycerophosphoethanolamine hydrolase activity
Biological Process
GO:0046485 ether lipid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1915505
InterPro IPR012506 YhhN-like
PFAM PF07947
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q497J1
PhosphoSite PhosphoSite-Q497J1
TrEMBL
UniProt Splice Variant
Entrez Gene 68255
UniGene Mm.389784
RefSeq NP_075929
MGI ID
MGI Symbol Tmem86b
OMIM
CCDS CCDS20739
HPRD
IMGT
EMBL BC100527
GenPept AAI00528

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca