InnateDB Protein
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IDBP-138530.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sept6
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Protein Name
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septin 6
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Synonyms
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2810035H17Rik; C920001C06Rik; mKIAA0128; Sep6;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000062014
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InnateDB Gene
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IDBG-138528 (Sept6)
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Protein Structure
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Function |
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis.
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Subcellular Localization |
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Associated with synaptic vesicles in various brain regions, including glomeruli of the olfactory bulb. {ECO:0000269PubMed:11064363}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
16 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1888939
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InterPro |
IPR000038
Cell division protein GTP binding
IPR016491
Septin
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00735
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PRINTS |
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PIRSF |
PIRSF006698
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9R1T4
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PhosphoSite |
PhosphoSite-Q9R1T4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56526
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UniGene |
Mm.470184
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RefSeq |
NP_064326
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MGI ID |
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MGI Symbol |
Sept6
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OMIM |
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CCDS |
CCDS30066
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HPRD |
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IMGT |
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EMBL |
AB023622
AK012858
AK048455
AK088406
AK088614
AK160884
AK162755
AK172894
AL450399
BC010489
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GenPept |
AAH10489
BAA82838
BAB28516
BAC33342
BAC40335
BAC40453
BAD32172
BAE36069
BAE37050
CAM19780
CAM19781
CAM19782
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