InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hspbp1

Summary

InnateDB Protein

IDBP-138597.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspbp1

Protein Name

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1

Synonyms

1500019G21Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078886

InnateDB Gene

IDBG-138595 (Hspbp1)

Protein Structure

UniProt Annotation

Function

Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0031398	positive regulation of protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)