Version 5.4
Mus musculus Protein: Ndufa2
Summary
InnateDB Protein IDBP-138618.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ndufa2
Protein Name NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2
Synonyms AV000592; B8; C1-B8; CI-B8;
Species Mus musculus
Ensembl Protein ENSMUSP00000014438
InnateDB Gene IDBG-138616 (Ndufa2)
Protein Structure
UniProt Annotation
Function Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008137 NADH dehydrogenase (ubiquinone) activity
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005747 mitochondrial respiratory chain complex I
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID MGI:1343103
InterPro IPR007741 Ribosomal protein/NADH dehydrogenase domain
IPR012336 Thioredoxin-like fold
IPR016464 NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2
PFAM PF05047
PF13098
PF13192
PF13462
PF13905
PRINTS
PIRSF PIRSF005822
SMART SM00916
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQ75
PhosphoSite PhosphoSite-Q9CQ75
TrEMBL
UniProt Splice Variant
Entrez Gene 17991
UniGene
RefSeq NP_035015
MGI ID
MGI Symbol Ndufa2
OMIM
CCDS CCDS29161
HPRD
IMGT
EMBL AF124786 AK003608 AK018732 BC006815
GenPept AAD30475 AAH06815 BAB22887 BAB31375

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca