InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Drg1

Summary

InnateDB Protein

IDBP-138849.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Drg1

Protein Name

developmentally regulated GTP binding protein 1

Synonyms

AA408859; AI132520; Nedd3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020741

InnateDB Gene

IDBG-138847 (Drg1)

Protein Structure

UniProt Annotation

Function

Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=The DRG1- DFRP2/ZC3H15 complex associates with polysomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Fairly high levels in liver, heart, kidney, testis and brain. Very low levels in lung, spleen, and skeletal muscle. {ECO:0000269PubMed:1280421}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity
GO:0042802	identical protein binding

Biological Process

GO:0015684

ferrous iron transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005844	polysome
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

MGI:1343297

InterPro

IPR004095 TGS
IPR005225 Small GTP-binding protein domain
IPR006073 GTP binding domain
IPR011619 Ferrous iron transport protein B, N-terminal
IPR012676 TGS-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02824
PF01926
PF02421

PRINTS

PR00326

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32233