Version 5.4
Mus musculus Protein: Dnd1
Summary
InnateDB Protein IDBP-138852.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dnd1
Protein Name dead end homolog 1 (zebrafish)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000054412
InnateDB Gene IDBG-138850 (Dnd1)
Protein Structure
UniProt Annotation
Function RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression (By similarity). Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs (By similarity). Sequence- specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs (By similarity). Does not bind to miRNAs (By similarity). Isoform 1 may play a role during primordial germ cell (PGC) survival. However, does not seem to be essential for PGC migration. {ECO:0000250}.
Subcellular Localization Nucleus. Cytoplasm. Note=Perinuclear germ granules, also called germ plasm or chromatoid body (By similarity). Colocalizes in perinuclear sites with APOBEC3. {ECO:0000250}.
Disease Associations Note=Defects in Dnd1 are the cause of the Ter mutation phenotype. Ter mice are characterized by primordial germ cell loss and susceptibility to spontaneous testicular germ cell tumors (TGCT). They are sterile, but viable. Isoform 1 defects may be the cause of tumor development. {ECO:0000269PubMed:15902260}.
Tissue Specificity Isoform 1 and isoform 2 are expressed in testis. Isoform 1 is expressed continuously in post natal (PN) testis although levels are low between PN1 to PN6. Isoform 2 is expressed from PN 20 onwards. Isoform 2 is strongly expressed in meiotic and in post-meiotic germ cells of the testis with highest expression at the elongated spermatid stage (at protein level). Expressed in testis and heart. Expressed in germ cells and genital ridges. Not detected in testicular tumors. {ECO:0000269PubMed:15902260, ECO:0000269PubMed:17291453}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0017091 AU-rich element binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007281 germ cell development
GO:0060965 negative regulation of gene silencing by miRNA
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2447763
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6VY05
PhosphoSite PhosphoSite-Q6VY05
TrEMBL
UniProt Splice Variant
Entrez Gene 213236
UniGene Mm.234464
RefSeq NP_775559
MGI ID
MGI Symbol Dnd1
OMIM
CCDS CCDS29163
HPRD
IMGT
EMBL AY321066 BC034897
GenPept AAH34897 AAQ63636

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca