Version 5.4
Mus musculus Protein: Orc5
Summary
InnateDB Protein IDBP-139208.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Orc5
Protein Name origin recognition complex, subunit 5
Synonyms AL033327; MmORC5; Orc5l;
Species Mus musculus
Ensembl Protein ENSMUSP00000030872
InnateDB Gene IDBG-139206 (Orc5)
Protein Structure
UniProt Annotation
Function Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication
Cellular Component
GO:0005634 nucleus
GO:0005664 nuclear origin of replication recognition complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1347044
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WUV0
PhosphoSite PhosphoSite-Q9WUV0
TrEMBL
UniProt Splice Variant
Entrez Gene 26429
UniGene Mm.483311
RefSeq NP_036089
MGI ID
MGI Symbol Orc5
OMIM
CCDS CCDS19110
HPRD
IMGT
EMBL AJ007360 AK084683 AK144983 AK165912 AK166537 BC006927
GenPept AAH06927 BAC39250 BAE26167 BAE38456 BAE38839 CAB43767

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca