Version 5.4
Mus musculus Protein: Fiz1
Summary
InnateDB Protein IDBP-139577.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fiz1
Protein Name Flt3 interacting zinc finger protein 1
Synonyms AI790204; mFLJ00416;
Species Mus musculus
Ensembl Protein ENSMUSP00000076603
InnateDB Gene IDBG-139575 (Fiz1)
Protein Structure
UniProt Annotation
Function May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10409713}. Nucleus {ECO:0000269PubMed:10409713}.
Disease Associations
Tissue Specificity Widely expressed. In the retina, highest expression in the ganglion cell layer. {ECO:0000269PubMed:10409713, ECO:0000269PubMed:12566383}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1344336
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WTJ4
PhosphoSite PhosphoSite-Q9WTJ4
TrEMBL Q3TRV0
UniProt Splice Variant
Entrez Gene 23877
UniGene Mm.38911
RefSeq NP_001103800
MGI ID
MGI Symbol Fiz1
OMIM
CCDS CCDS20751
HPRD
IMGT
EMBL AF126746 AF126747 AK003641 AK142205 AK162454 AK170633 BC006633 BC106113 BC138231 BC138232 BC145207 CH466627
GenPept AAD45498 AAD45499 AAH06633 AAI06114 AAI38232 AAI38233 AAI45208 BAB22907 BAE24975 BAE36926 BAE41925 EDL31276

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca