InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bmi1

Summary

InnateDB Protein

IDBP-139746.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmi1

Protein Name

Bmi1 polycomb ring finger oncogene

Synonyms

AW546694; Bmi-1; Pcgf4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028071

InnateDB Gene

IDBG-139744 (Bmi1)

Protein Structure

UniProt Annotation

Function

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in most organs with high expression levels in thymus, heart, brain and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	65 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001701	in utero embryonic development
GO:0006306	DNA methylation
GO:0006351	transcription, DNA-templated
GO:0006959	humoral immune response
GO:0007420	brain development
GO:0009987	cellular process
GO:0016573	histone acetylation
GO:0016574	histone ubiquitination
GO:0021903	rostrocaudal neural tube patterning
GO:0030890	positive regulation of B cell proliferation
GO:0033092	positive regulation of immature T cell proliferation in thymus
GO:0048103	somatic stem cell division
GO:0048704	embryonic skeletal system morphogenesis
GO:0048706	embryonic skeletal system development
GO:0051443	positive regulation of ubiquitin-protein transferase activity
GO:2001234	negative regulation of apoptotic signaling pathway