InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ckap2

Summary

InnateDB Protein

IDBP-139997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ckap2

Protein Name

cytoskeleton associated protein 2

Synonyms

AI461656; AW228814; LB1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039518

InnateDB Gene

IDBG-139995 (Ckap2)

Protein Structure

UniProt Annotation

Function

Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53- dependent manner. {ECO:0000269PubMed:15504249, ECO:0000269PubMed:16061649}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome- proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006915	apoptotic process
GO:0007026	negative regulation of microtubule depolymerization
GO:0045944	positive regulation of transcription from RNA polymerase II promoter