Version 5.4
Mus musculus Protein: Msrb2
Summary
InnateDB Protein IDBP-140064.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Msrb2
Protein Name methionine sulfoxide reductase B2
Synonyms 2310050L06Rik; Mrsb; Msrb; Pilb;
Species Mus musculus
Ensembl Protein ENSMUSP00000023856
InnateDB Gene IDBG-140062 (Msrb2)
Protein Structure
UniProt Annotation
Function Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post- translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. {ECO:0000269PubMed:14699060, ECO:0000269PubMed:23911929}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:14699060}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0008270 zinc ion binding
GO:0033743 peptide-methionine (R)-S-oxide reductase activity
Biological Process
GO:0006979 response to oxidative stress
GO:0030041 actin filament polymerization
GO:0030091 protein repair
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:1923717
InterPro IPR002579 Peptide methionine sulphoxide reductase MrsB
IPR011057 Mss4-like
PFAM PF01641
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q78J03
PhosphoSite PhosphoSite-Q78J03
TrEMBL
UniProt Splice Variant
Entrez Gene 76467
UniGene Mm.27166
RefSeq NP_083895
MGI ID 2L1U
MGI Symbol Msrb2
OMIM
CCDS CCDS15714
HPRD
IMGT
EMBL AL928806 BC021619
GenPept AAH21619 CAM21786

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca