InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stoml2

Summary

InnateDB Protein

IDBP-140082.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stoml2

Protein Name

stomatin (Epb7.2)-like 2

Synonyms

0610038F01Rik; MSLP2; SLP-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030169

InnateDB Gene

IDBG-140080 (Stoml2)

Protein Structure

UniProt Annotation

Function

Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. {ECO:0000269PubMed:19360003, ECO:0000269PubMed:23028053}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:22623988}. Mitochondrion intermembrane space {ECO:0000269PubMed:22623988}. Cell membrane {ECO:0000269PubMed:22623988}; Peripheral membrane protein {ECO:0000269PubMed:22623988}. Membrane raft {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain. A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells. Also associates with the actin cytoskeleton and membrane rafts in activated T-cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:1901612	cardiolipin binding

Biological Process

GO:0006851	mitochondrial calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0007005	mitochondrion organization
GO:0010876	lipid localization
GO:0010918	positive regulation of mitochondrial membrane potential
GO:0032623	interleukin-2 production
GO:0034982	mitochondrial protein processing
GO:0035710	CD4-positive, alpha-beta T cell activation
GO:0042776	mitochondrial ATP synthesis coupled proton transport
GO:0050852	T cell receptor signaling pathway
GO:0051259	protein oligomerization
GO:0090297	positive regulation of mitochondrial DNA replication
GO:1900210	positive regulation of cardiolipin metabolic process
GO:1990046	stress-induced mitochondrial fusion

Cellular Component

GO:0001772	immunological synapse
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0008180	COP9 signalosome
GO:0015629	actin cytoskeleton
GO:0019897	extrinsic component of plasma membrane
GO:0042101	T cell receptor complex
GO:0045121	membrane raft