InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Taf7

Summary

InnateDB Protein

IDBP-140094.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Taf7

Protein Name

TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor

Synonyms

55kDa; AI607308; BB007175; Taf2f; TAFII55;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065645

InnateDB Gene

IDBG-140092 (Taf7)

Protein Structure

UniProt Annotation

Function

Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035035	histone acetyltransferase binding
GO:0042809	vitamin D receptor binding
GO:0044212	transcription regulatory region DNA binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006352	DNA-templated transcription, initiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006469	negative regulation of protein kinase activity
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0035067	negative regulation of histone acetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0008024	positive transcription elongation factor complex b
GO:0033276	transcription factor TFTC complex
GO:0071339	MLL1 complex